Virus Nipah l\u00e0 m\u1ed9t m\u1ed1i \u0111e d\u1ecda nghi\u00eam tr\u1ecdng \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u do t\u1ef7 l\u1ec7 t\u1eed vong cao v\u00e0 kh\u1ea3 n\u0103ng l\u00e2y lan gi\u1eefa \u0111\u1ed9ng v\u1eadt v\u00e0 con ng\u01b0\u1eddi, th\u1eadm ch\u00ed t\u1eeb ng\u01b0\u1eddi sang ng\u01b0\u1eddi. Virus ch\u1ee7 y\u1ebfu l\u00e2y truy\u1ec1n qua d\u01a1i ho\u1eb7c c\u00e1c \u0111\u1ed9ng v\u1eadt trung gian nh\u01b0 l\u1ee3n, g\u00e2y ra c\u00e1c b\u1ec7nh h\u00f4 h\u1ea5p nghi\u00eam tr\u1ecdng v\u00e0 vi\u00eam n\u00e3o. Cho \u0111\u1ebfn nay, ch\u01b0a c\u00f3 v\u1eafc-xin ho\u1eb7c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0o \u0111\u01b0\u1ee3c ph\u00ea duy\u1ec7t \u0111\u1ec3 ch\u1ed1ng l\u1ea1i virus n\u00e0y.<\/p>\n
M\u1ed9t nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 th\u1eed nghi\u1ec7m m\u1ed9t lo\u1ea1i v\u1eafc-xin mRNA m\u1edbi, c\u00f3 t\u00ean mRNA-1215, \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i virus n\u00e0y. B\u1ed1n m\u01b0\u01a1i ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh kh\u1ecfe m\u1ea1nh \u0111\u00e3 tham gia th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 1 n\u00e0y. H\u1ecd \u0111\u01b0\u1ee3c ti\u00eam hai li\u1ec1u v\u1eafc-xin c\u00e1ch nhau b\u1ed1n tu\u1ea7n, v\u1edbi li\u1ec1u l\u01b0\u1ee3ng kh\u00e1c nhau t\u1eeb 10 \u0111\u1ebfn 100 microgam. K\u1ebft qu\u1ea3 cho th\u1ea5y v\u1eafc-xin \u0111\u01b0\u1ee3c dung n\u1ea1p t\u1ed1t. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 \u0111au nh\u1eb9 t\u1ea1i ch\u1ed7 ti\u00eam v\u00e0 c\u1ea3m gi\u00e1c m\u1ec7t m\u1ecfi tho\u00e1ng qua. Kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng n\u00e0o \u0111\u01b0\u1ee3c ghi nh\u1eadn, x\u00e1c nh\u1eadn t\u00ednh an to\u00e0n c\u1ee7a s\u1ea3n ph\u1ea9m.<\/p>\n
Ch\u1ec9 hai tu\u1ea7n sau li\u1ec1u ti\u00eam \u0111\u1ea7u ti\u00ean, v\u1eafc-xin \u0111\u00e3 k\u00edch th\u00edch s\u1ea3n sinh kh\u00e1ng th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng trung h\u00f2a virus. Ph\u1ea3n \u1ee9ng n\u00e0y \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng sau li\u1ec1u th\u1ee9 hai v\u00e0 duy tr\u00ec \u1edf m\u1ee9c cao trong \u00edt nh\u1ea5t m\u1ed9t n\u0103m. V\u1eafc-xin c\u0169ng k\u00edch th\u00edch ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i c\u00e1c ch\u1ee7ng virus g\u1ea7n g\u0169i v\u1edbi virus Nipah, ch\u1eb3ng h\u1ea1n nh\u01b0 ch\u1ee7ng c\u00f3 m\u1eb7t \u1edf Bangladesh, c\u0169ng nh\u01b0 ch\u1ed1ng l\u1ea1i m\u1ed9t lo\u1ea1i virus li\u00ean quan, virus Hendra. \u0110i\u1ec1u n\u00e0y g\u1ee3i \u00fd r\u1eb1ng v\u1eafc-xin c\u00f3 th\u1ec3 mang l\u1ea1i s\u1ef1 b\u1ea3o v\u1ec7 r\u1ed9ng r\u00e3i ch\u1ed1ng l\u1ea1i nhi\u1ec1u b\u1ec7nh t\u01b0\u01a1ng t\u1ef1.<\/p>\n
Ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch t\u01b0\u01a1ng \u0111\u01b0\u01a1ng \u1edf t\u1ea5t c\u1ea3 c\u00e1c li\u1ec1u l\u01b0\u1ee3ng \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m, m\u1eb7c d\u00f9 c\u00e1c li\u1ec1u cao h\u01a1n duy tr\u00ec m\u1ee9c kh\u00e1ng th\u1ec3 \u1ed5n \u0111\u1ecbnh h\u01a1n m\u1ed9t ch\u00fat trong th\u1eddi gian d\u00e0i. Nh\u1eefng ng\u01b0\u1eddi tham gia \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u1ea3 kh\u00e1ng th\u1ec3 v\u00e0 t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u1eb7c hi\u1ec7u, \u0111i\u1ec1u c\u1ea7n thi\u1ebft cho s\u1ef1 b\u1ea3o v\u1ec7 hi\u1ec7u qu\u1ea3.<\/p>\n
V\u1eafc-xin n\u00e0y s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn \u0111\u1ed5i m\u1edbi b\u1eb1ng c\u00e1ch nh\u1eafm m\u1ee5c ti\u00eau hai protein c\u1ee7a virus thay v\u00ec ch\u1ec9 m\u1ed9t, gi\u00fap t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 v\u00e0 gi\u1ea3m nguy c\u01a1 virus tho\u00e1t kh\u1ecfi ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch. Nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u1ea7y tri\u1ec3n v\u1ecdng n\u00e0y m\u1edf \u0111\u01b0\u1eddng cho c\u00e1c th\u1eed nghi\u1ec7m b\u1ed5 sung, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng khu v\u1ef1c virus Nipah l\u01b0u h\u00e0nh th\u01b0\u1eddng xuy\u00ean. M\u1ed9t b\u01b0\u1edbc ti\u1ebfn nh\u01b0 v\u1eady c\u00f3 th\u1ec3 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ph\u00f2ng ng\u1eeba c\u00e1c \u0111\u1ee3t b\u00f9ng ph\u00e1t d\u1ecbch trong t\u01b0\u01a1ng lai.<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41591-026-04265-1<\/a><\/p>\n Titre\u00a0:<\/strong> A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial<\/p>\n Revue : <\/strong> Nature Medicine<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Aur\u00e9lie Ploquin; Rosemarie D. Mason; LaSonji A. Holman; Myra Happe; Alicia T. Widge; Laura Novik; Ana M. Ortega-Villa; Galina V. Yamshchikov; Ingelise J. Gordon; Abidemi Ola; Anita Arthur; Pamela J. M. Costner; Floreliz Mendoza; Jamie Saunders; Xioalin Wang; William R. Whalen; Joanna Utoh; Jennifer Cunningham; Lorin N. Loftus; Ashley Heimann; Katia Korzeniwsky; Shayne F. Andrew; Evan Lamb; Shruthi Shyam Sunder; Amelia Thompson; Mary McDonald; Kathryn E. Foulds; Nancy J. Sullivan; Jessica Bahorich; Emily E. Coates; Rebecca J. Loomis; Barney S. Graham; Karin Bok; Sunny Himansu; Brett Leav; Walla Dempsey; John H. Beigel; Mario Roederer; Lesia K. Dropulic; ; Maxwell Norris; Preeti Apte; Renunda Dyer; LaShawn Requilman; Justine Jones; Larisa Strom; Tatiana Beresnev; Maryam Keshtkar-Jahromi; Caitlyn Dulan; Li Ou; I-Ting Teng; Tongqing Zhou<\/p>\n","protected":false},"excerpt":{"rendered":" V\u1eafc-xin mRNA \u0111\u1ea7y h\u1ee9a h\u1eb9n ch\u1ed1ng l\u1ea1i virus Nipah cho th\u1ea5y kh\u1ea3 n\u0103ng dung n\u1ea1p t\u1ed1t v\u00e0 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch l\u00e2u d\u00e0i Virus Nipah l\u00e0 m\u1ed9t m\u1ed1i \u0111e d\u1ecda nghi\u00eam tr\u1ecdng \u0111\u1ed1i v\u1edbi s\u1ee9c kh\u1ecfe to\u00e0n c\u1ea7u do t\u1ef7 l\u1ec7 t\u1eed vong cao v\u00e0 kh\u1ea3 n\u0103ng l\u00e2y lan gi\u1eefa \u0111\u1ed9ng v\u1eadt v\u00e0 con ng\u01b0\u1eddi,… Continue reading V\u1eafc-xin mRNA \u0111\u1ea7y h\u1ee9a h\u1eb9n ch\u1ed1ng l\u1ea1i virus Nipah cho th\u1ea5y kh\u1ea3 n\u0103ng dung n\u1ea1p t\u1ed1t v\u00e0 ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch l\u00e2u d\u00e0i<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,3],"tags":[],"class_list":["post-15","post","type-post","status-publish","format-standard","hentry","category-suc-khoe","category-the-thao","entry"],"_links":{"self":[{"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/posts\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":1,"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions"}],"predecessor-version":[{"id":16,"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions\/16"}],"wp:attachment":[{"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/media?parent=15"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/categories?post=15"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thepublichealthreview.com\/vi\/wp-json\/wp\/v2\/tags?post=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}