Alopecia areata, sa\u00e7l\u0131 deri, ka\u015flar, kirpikler ve bazen t\u00fcm v\u00fccutta ani sa\u00e7 d\u00f6k\u00fclmesine neden olan otoimm\u00fcn bir hastal\u0131kt\u0131r. Hem yeti\u015fkinleri hem de gen\u00e7leri etkiler ve ya\u015fam kalitesini d\u00fc\u015f\u00fcrerek \u00f6nemli psikolojik etkiler yaratabilir. Yak\u0131n zamana kadar, \u015fiddetli vakalar i\u00e7in tedavi se\u00e7enekleri s\u0131n\u0131rl\u0131 ve tatmin edici de\u011fildi.<\/p>\n
2023 y\u0131l\u0131ndan beri onaylanan ritlecitinib adl\u0131 oral bir ila\u00e7, yeni umutlar sunuyor. Bu tedavi, sa\u00e7 k\u00f6klerinin tahribat\u0131nda rol oynayan ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin belirli yollar\u0131n\u0131 hedef alarak mod\u00fcle ediyor. \u0130talya’da yirmi \u00fcniversite hastanesinde y\u00fcr\u00fct\u00fclen bir \u00e7al\u0131\u015fma, 12 ya\u015f ve \u00fcst\u00fc 102 \u015fiddetli alopecia areata hastas\u0131nda ilac\u0131n etkinli\u011fini ve tolerans\u0131n\u0131 de\u011ferlendirdi. G\u00fcnde 50 mg dozunda 24 haftal\u0131k tedaviden sonra, kat\u0131l\u0131mc\u0131lar\u0131n yakla\u015f\u0131k %40’\u0131 sa\u00e7l\u0131 deride sa\u00e7lar\u0131n anlaml\u0131 \u015fekilde yeniden \u00e7\u0131kmas\u0131n\u0131, en az %80 kaplama ile g\u00f6zlemledi. Sonu\u00e7lar, \u00f6zellikle gen\u00e7lerde umut vericiydi; gen\u00e7lerin neredeyse yar\u0131s\u0131 olumlu yan\u0131t verirken, yeti\u015fkinlerde bu oran sadece be\u015fte birdi.<\/p>\n
\u0130yile\u015fme sadece sa\u00e7l\u0131 deri ile s\u0131n\u0131rl\u0131 kalmad\u0131. Hastal\u0131ktan s\u0131k\u00e7a etkilenen ka\u015flar, kirpikler ve t\u0131rnaklar da iyile\u015fme belirtileri g\u00f6sterdi. Sa\u00e7 ve sa\u00e7l\u0131 derinin b\u00fcy\u00fct\u00fclm\u00fc\u015f g\u00f6r\u00fcnt\u00fclerini incelemeyi sa\u011flayan trikoskopik muayeneler, iltihap belirtilerinde azalma ve sa\u00e7lar\u0131n yeniden \u00e7\u0131kma faz\u0131nda art\u0131\u015f oldu\u011funu do\u011frulad\u0131. Ayr\u0131ca, hastalar psikolojik refahlar\u0131nda ve g\u00fcnl\u00fck ya\u015famlar\u0131nda belirgin bir iyile\u015fme, hastal\u0131kla ili\u015fkili anksiyete ve depresyonun azalmas\u0131n\u0131 bildirdiler.<\/p>\n
Ritlecitinib genel olarak iyi tolere edildi. Akne veya ba\u015f a\u011fr\u0131s\u0131 gibi g\u00f6zlemlenen yan etkiler hafif ve y\u00f6netilebilir d\u00fczeyde kald\u0131. Sadece bir \u015fiddetli anemi vakas\u0131 tedavinin kesilmesini gerektirdi. Daha \u00f6nceki klinik deneylerde g\u00f6zlemlenen g\u00fcvenlik profili do\u011fruland\u0131, ciddi bir yan etki bildirilmedi.<\/p>\n
Ger\u00e7ek ya\u015fam ko\u015fullar\u0131nda yap\u0131lan bu \u00e7al\u0131\u015fma, \u00f6zellikle gen\u00e7ler olmak \u00fczere \u015fiddetli alopecia areata ile m\u00fccadele edenler i\u00e7in umutlar\u0131 art\u0131r\u0131yor. \u00c7al\u0131\u015fma, ritlecitinib’in sadece sa\u00e7lar\u0131 de\u011fil, ayn\u0131 zamanda g\u00fcnl\u00fck ya\u015famda g\u00fcven ve konforu da geri kazand\u0131rabilece\u011fini g\u00f6steriyor. Ancak, ara\u015ft\u0131rmac\u0131lar, sonu\u00e7lar\u0131n kal\u0131c\u0131l\u0131\u011f\u0131n\u0131 do\u011frulamak ve tedavi stratejilerini iyile\u015ftirmek i\u00e7in uzun vadeli g\u00f6zlemlerin s\u00fcrd\u00fcr\u00fclmesi gerekti\u011fini vurguluyor.<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s40257-026-01022-5<\/a><\/p>\n Titre\u00a0:<\/strong> Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study<\/p>\n Revue : <\/strong> American Journal of Clinical Dermatology<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Michela Starace; Luca Rapparini; Francesca Pampaloni; Stephano Cedirian; Federico Quadrelli; Francesca Bruni; Ginevra Martelli; Giampiero Girolomoni; Francesco Bellinato; Paolo Gisondi; Giuseppe Gallo; Simone Ribero; Michela Ortoncelli; Pietro Quaglino; Luigi Gargiulo; Carlo Vignoli; Alessandra Narcisi; Francesca Ambrogio; Caterina Foti; Raffaele Dante Caposiena Caro; Iris Zalaudek; Angelo Valerio Marzano; Andrea Sechi; Mauro Barbareschi; Luca Valtellini; Silvia Mariel Ferrucci; Laura Diluvio; Enrico Matteini; Luca Bianchi; Mariateresa Cantelli; Paola Nappa; Carolina D\u2019Elia; Valeria Boccaletti; Carola Roman\u00f2; Elisabetta Fulgione; Anna Balato; Giuseppe Argenziano; Emanuele Trovato; Elisa Cinotti; Pietro Rubegni; Federica Dall\u2019Oglio; Francesco Lacarrubba; Giuseppe Micali; Elena Pezzolo; Francesca Caroppo; Anna Belloni Fortina; Giacomo Caldarola; Ketty Peris; Lorenzo Maria Pinto; Calogero Pagliarello; Riccardo Balestri; Carlo Tomasini; Stefania Barruscotti; Laura Atzori; Silvia Sanna; Lorenzo Ala; Giulio Bortone; Giovanni Pellacani; Alfredo Rossi; Serena Lembo; Annunziata Raimondo; Flavia Manzo Margiotta; Valentina Dini; Marco Romanelli; Andrea Megna; Francesca Prignano; Gianmarco Silvi; Oriana Simonetti; Edoardo De Simoni; Michela Magnano; Natale Schettini; \u2060\u2060Alessandro Borghi; Francesca Satolli; Maria Beatrice de Felici del Giudice; Franco Rongioletti; Stefania Guida; Gianmarco Diego Bigotto; Cesare Filippeschi; Teresa Oranges; Greta Tronconi; Bianca Maria Piraccini<\/p>\n","protected":false},"excerpt":{"rendered":" Yeni Bir Tedavi, \u015eiddetli Alopecia Areata Hastalar\u0131na Umut Veriyor Alopecia areata, sa\u00e7l\u0131 deri, ka\u015flar, kirpikler ve bazen t\u00fcm v\u00fccutta ani sa\u00e7 d\u00f6k\u00fclmesine neden olan otoimm\u00fcn bir hastal\u0131kt\u0131r. Hem yeti\u015fkinleri hem de gen\u00e7leri etkiler ve ya\u015fam kalitesini d\u00fc\u015f\u00fcrerek \u00f6nemli psikolojik etkiler yaratabilir. Yak\u0131n zamana kadar, \u015fiddetli vakalar i\u00e7in tedavi se\u00e7enekleri s\u0131n\u0131rl\u0131 ve tatmin edici de\u011fildi. 2023… Okumaya devam et Yeni Bir Tedavi, \u015eiddetli Alopecia Areata Hastalar\u0131na Umut Veriyor<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,2],"tags":[],"class_list":["post-19","post","type-post","status-publish","format-standard","hentry","category-insan-insani","category-saglik","entry"],"_links":{"self":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts\/19","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/comments?post=19"}],"version-history":[{"count":1,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts\/19\/revisions"}],"predecessor-version":[{"id":20,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts\/19\/revisions\/20"}],"wp:attachment":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/media?parent=19"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/categories?post=19"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/tags?post=19"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}