Nipah vir\u00fcs\u00fc, y\u00fcksek \u00f6l\u00fcm oran\u0131 ve hayvanlar ile insanlar aras\u0131nda, hatta ki\u015fiden ki\u015fiye yay\u0131lma yetene\u011fi nedeniyle k\u00fcresel sa\u011fl\u0131k i\u00e7in ciddi bir tehdit olu\u015fturmaktad\u0131r. Ba\u015fl\u0131ca yarasalar veya domuzlar gibi ara hayvanlar arac\u0131l\u0131\u011f\u0131yla bula\u015fan vir\u00fcs, a\u011f\u0131r solunum yolu hastal\u0131klar\u0131na ve ensefalite neden olmaktad\u0131r. \u015eu ana kadar bu vir\u00fcse kar\u015f\u0131 onaylanm\u0131\u015f bir a\u015f\u0131 veya tedavi bulunmamaktayd\u0131.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar, bu vir\u00fcse kar\u015f\u0131 koruma sa\u011flamak \u00fczere tasarlanm\u0131\u015f yeni bir mRNA a\u015f\u0131s\u0131n\u0131, mRNA-1215’i test etti. Sa\u011fl\u0131kl\u0131 40 yeti\u015fkin, faz 1 klinik deneyine kat\u0131ld\u0131. Kat\u0131l\u0131mc\u0131lar, d\u00f6rt hafta arayla, 10 ila 100 mikrogram aras\u0131nda de\u011fi\u015fen dozlarda a\u015f\u0131 oldular. Sonu\u00e7lar, a\u015f\u0131n\u0131n iyi tolere edildi\u011fini g\u00f6sterdi. En s\u0131k g\u00f6r\u00fclen yan etkiler, enjeksiyon yerinde hafif a\u011fr\u0131 ve ge\u00e7ici yorgunluk hissiydi. Ciddi bir yan etki g\u00f6zlenmedi, bu da \u00fcr\u00fcn\u00fcn g\u00fcvenli\u011fini do\u011frulad\u0131.<\/p>\n
\u0130lk enjeksiyondan sadece iki hafta sonra a\u015f\u0131, vir\u00fcs\u00fc n\u00f6tralize edebilen antikorlar\u0131n \u00fcretimini tetikledi. Bu yan\u0131t, ikinci doz sonras\u0131nda g\u00fc\u00e7lendi ve en az bir y\u0131l boyunca y\u00fcksek seviyede kald\u0131. A\u015f\u0131, ayr\u0131ca Nipah vir\u00fcs\u00fcn\u00fcn Banglade\u015f’te bulunan gibi yak\u0131n su\u015flar\u0131na ve akraba bir vir\u00fcs olan Hendra vir\u00fcs\u00fcne kar\u015f\u0131 da ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131tlar\u0131n\u0131 uyard\u0131. Bu da benzer birka\u00e7 hastal\u0131\u011fa kar\u015f\u0131 geni\u015fletilmi\u015f bir koruma sa\u011flayabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n
Ba\u011f\u0131\u015f\u0131kl\u0131k tepkileri, test edilen t\u00fcm dozlar i\u00e7in benzerdi, ancak daha y\u00fcksek dozlar, uzun vadede antikor seviyelerini biraz daha stabil tuttu. Kat\u0131l\u0131mc\u0131lar, etkili bir koruma i\u00e7in \u00f6nemli olan hem antikorlar hem de spesifik ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri geli\u015ftirdiler.<\/p>\n
Bu a\u015f\u0131, vir\u00fcs\u00fcn iki proteinini hedef alarak tek bir protein yerine yenilik\u00e7i bir yakla\u015f\u0131m kullan\u0131yor, bu da etkinli\u011fini art\u0131r\u0131yor ve vir\u00fcs\u00fcn ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131ndan ka\u00e7ma riskini azalt\u0131yor. Bu cesaret verici sonu\u00e7lar, \u00f6zellikle Nipah vir\u00fcs\u00fcn\u00fcn d\u00fczenli olarak dola\u015ft\u0131\u011f\u0131 b\u00f6lgelerde ek deneylerin yolunu a\u00e7\u0131yor. B\u00f6yle bir ilerleme, gelecekteki salg\u0131nlar\u0131n \u00f6nlenmesinde kilit bir rol oynayabilir.<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1038\/s41591-026-04265-1<\/a><\/p>\n Titre\u00a0:<\/strong> A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial<\/p>\n Revue : <\/strong> Nature Medicine<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Aur\u00e9lie Ploquin; Rosemarie D. Mason; LaSonji A. Holman; Myra Happe; Alicia T. Widge; Laura Novik; Ana M. Ortega-Villa; Galina V. Yamshchikov; Ingelise J. Gordon; Abidemi Ola; Anita Arthur; Pamela J. M. Costner; Floreliz Mendoza; Jamie Saunders; Xioalin Wang; William R. Whalen; Joanna Utoh; Jennifer Cunningham; Lorin N. Loftus; Ashley Heimann; Katia Korzeniwsky; Shayne F. Andrew; Evan Lamb; Shruthi Shyam Sunder; Amelia Thompson; Mary McDonald; Kathryn E. Foulds; Nancy J. Sullivan; Jessica Bahorich; Emily E. Coates; Rebecca J. Loomis; Barney S. Graham; Karin Bok; Sunny Himansu; Brett Leav; Walla Dempsey; John H. Beigel; Mario Roederer; Lesia K. Dropulic; ; Maxwell Norris; Preeti Apte; Renunda Dyer; LaShawn Requilman; Justine Jones; Larisa Strom; Tatiana Beresnev; Maryam Keshtkar-Jahromi; Caitlyn Dulan; Li Ou; I-Ting Teng; Tongqing Zhou<\/p>\n","protected":false},"excerpt":{"rendered":" Nipah vir\u00fcs\u00fcne kar\u015f\u0131 umut vaat eden bir mRNA a\u015f\u0131s\u0131, iyi tolerans ve s\u00fcrd\u00fcr\u00fclebilir ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 g\u00f6sterdi Nipah vir\u00fcs\u00fc, y\u00fcksek \u00f6l\u00fcm oran\u0131 ve hayvanlar ile insanlar aras\u0131nda, hatta ki\u015fiden ki\u015fiye yay\u0131lma yetene\u011fi nedeniyle k\u00fcresel sa\u011fl\u0131k i\u00e7in ciddi bir tehdit olu\u015fturmaktad\u0131r. Ba\u015fl\u0131ca yarasalar veya domuzlar gibi ara hayvanlar arac\u0131l\u0131\u011f\u0131yla bula\u015fan vir\u00fcs, a\u011f\u0131r solunum yolu hastal\u0131klar\u0131na ve ensefalite… Okumaya devam et Nipah vir\u00fcs\u00fcne kar\u015f\u0131 umut vaat eden bir mRNA a\u015f\u0131s\u0131, iyi tolerans ve s\u00fcrd\u00fcr\u00fclebilir ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 g\u00f6sterdi<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,3],"tags":[],"class_list":["post-15","post","type-post","status-publish","format-standard","hentry","category-saglik","category-spor","entry"],"_links":{"self":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":1,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts\/15\/revisions"}],"predecessor-version":[{"id":16,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/posts\/15\/revisions\/16"}],"wp:attachment":[{"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/media?parent=15"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/categories?post=15"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/thepublichealthreview.com\/tr\/wp-json\/wp\/v2\/tags?post=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}